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Both are considered equally safe and efficacious. It is recommended that a vaccine series be initiated and completed with the same vaccine product; however, decreased efficacy or increased frequency of adverse reactions have not been documented when the series is initiated with one vaccine product and completed with another.
The rabies vaccine series induces an active immune response that requires 7 to 10 days to develop and persists for many years. Previously vaccinated individuals are those who have completed a pre-exposure or post-exposure regimen of human diploid cell vaccine HDCV or purified chick embryo cell vaccine PCEC , or who have received a different vaccine outside of the U. Following an exposure, previously vaccinated persons are given two 1. No HRIG is administered. Every effort should be made to adhere to the recommended PEP regimen schedule, especially the first two days of treatment, days 0 and 3.
After day 3 of the regimen, deviations of a few days are acceptable. For most minor delays or interruptions, the vaccination schedule can be shifted and resumed as though the patient were on schedule. For example, if a patient misses the dose scheduled for day 7 and presents for vaccination on day 10, the day 7 dose should be administered that day, and the final dose given one week later on day Please consult MDH epidemiologists for advice when substantial deviations from the recommended schedule have occurred.
Rabies vaccine. People at high risk of exposure to rabies should be offered pre-exposure rabies vaccination, including: Veterinarians, animal handlers, and veterinary students Rabies laboratory workers Spelunkers people who explore caves , and Persons who work with live vaccine to produce rabies vaccine and rabies immune globulin.
Pre-exposure rabies vaccination should also be considered for: People whose activities bring them into frequent contact with rabies virus or with possibly rabid animals.
International travelers who are likely to come in contact with animals in parts of the world where rabies is common and immediate access to appropriate care is limited. For post-exposure protection: A person who is exposed and has never been vaccinated against rabies should get 4 doses of rabies vaccine.
The person should also get another shot called rabies immune globulin RIG. A person who has been previously vaccinated should get 2 doses of rabies vaccine and does not need Rabies Immune Globulin. Your health care provider can give you more information. Talk with your health care provider. Tell your vaccine provider if the person getting the vaccine: Has had an allergic reaction after a previous dose of rabies vaccine , or has any severe, life-threatening allergies.
Has a weakened immune system. Risks of a vaccine reaction. Soreness, redness, swelling, or itching at the site of the injection, and headache, nausea, abdominal pain, muscle aches, or dizziness can happen after rabies vaccine. Hives, pain in the joints, or fever sometimes happen after booster doses.
What if there is a serious problem? For other signs that concern you, call your health care provider.
Ask your health care provider. Call your local or state health department. Office Use Only. Related Link.
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